Ponce Health Sciences University
Contact: psantiago@psm.edu
Professional Preparation
– Ph.D. in Biology, University of Puerto Rico
-Postdoctoral Training: Pathology Department, Harvard Medical School, Molecular Oncology Research Institute, Tufts Medical center
Publications
-The Retinoblastoma Protein in Osteogenesis and Osteosarcoma Formation. (2012). Pedro G. Santiago-Cardona. Osteogenesis (Yunfeng Lin, Ed.), Chapter 10, pp. 253-286. InTech. ISBN: 978-953-51-0030-0. http://www.intechopen.com/articles/show/title/-the-retinoblastoma-protein-in-osteogenesis-and-osteosarcoma-formation-.
-A Novel Role for the Retinoblastoma Tumor Suppressor Protein as a Regulator of Cell Adhesion: Implications for Osteogenic Differentiation and Osteosarcoma Formation. Bernadette Sosa, Volkan Gunduz, Viviana Vázquez-Rivera, W. Douglas Cress, Gabriela Wright, Haikuo Bian, Philip W. Hinds and Pedro G. Santiago-Cardona. (2010). PLoS ONE 5(11): e13954. doi:10.1371/journal.pone.0013954. PMID: 21085651.
-Yang H.-S., Alexander K., Santiago P., and Hinds P. W. (2003). ERM proteins and Cdk5 in cellular senescence. Cell Cycle, 2(6): 517-520. PMID: 14504464.
Ongoing Research/Grants
1U54CA163071-01A1 Santiago, P. (Co-Leader) 08/01/12 – 08/31/15
NIH/NCI 2.4 CM $123,750/yr (Total direct cost = $371,250)
Title: Molecular Biology of Lung Cancer among Puerto Ricans
The goals for this study are: 1) to determine the mutation status of genes commonly mutated in human lung cancer and the functional status of the CDKN2A/RB1 pathway in a large panel of Puerto Rican NSCLC patients. 2) to perform mRNA expression analysis on samples from Aim 1 to compare gene expression profiles and to correlate mutation data from Aim 1 with expression profiles. 3) to characterize the detailed mechanisms by which pRb regulates cell adhesion.